Docetaxel (Taxotere) and Prostate Cancer

  1. Docetaxel (Taxotere) and Prostate Cancer
  2. How long does docetaxel work for prostate?
  3. Does docetaxel reduce PSA?
  4. How is docetaxel administered for prostate cancer?
  5. What is the success rate of docetaxel?
  6. How long does docetaxel extend life?
  7. How long can you stay on docetaxel?
  8. What is the most common side effect of docetaxel?
  9. Can chemo raise PSA levels?
  10. Does PSA go down after chemo?
  11. Can Taxotere cure prostate cancer?
  12. Is Taxotere a good chemo drug?
  13. How good is Taxotere?
  14. How good is docetaxel?
  15. What is after docetaxel?
  16. Does docetaxel cause eye problems?
  17. Is docetaxel well tolerated?
  18. Is docetaxel a pill?
  19. Is enzalutamide better than docetaxel?
  20. Does Taxotere cause bone pain?
  21. Does docetaxel shrink tumors?
  22. Which stage does docetaxel work?
  23. How does docetaxel affect the body?
  24. Does docetaxel cause kidney damage?
  25. What are the cumulative side effects of Taxotere?
  26. What is the average PSA for a 70 year old?
  27. What is the highest PSA level ever recorded?
  28. What is the highest PSA level a man can have?
  29. What does a PSA level of 100 mean?
  30. What should my PSA level be after a prostatectomy?
  31. What does a PSA of 500 mean?
  32. What is the success rate of Taxotere?
  33. Is prostate cancer treated with chemotherapy?
  34. Is chemotherapy good for prostate cancer?
  35. Which is worse FEC or docetaxel?
  36. How long does it take to recover from docetaxel?
  37. Which is stronger Taxol or Taxotere?
  38. How common is permanent hair loss with Taxotere?
  39. Does docetaxel cause neuropathy?
  40. How long does it take to administer docetaxel?
  41. What is the mechanism of action of docetaxel?
  42. What company makes xtandi?
  43. How effective is enzalutamide?
  44. How many cycles of docetaxel can you have?
  45. Is docetaxel an immunotherapy?
  46. Does docetaxel cause heart problems?
  47. Can Taxotere cause blindness?
  48. Does docetaxel cause watery eyes?
  49. Does Taxotere cause blurry vision?

Docetaxel (Taxotere) and Prostate Cancer

With an overall prostate-specific antigen response hasten of 42% in four Phase II studies, docetaxel has significant single-agent agility in androgen-independent prostate cancer. Phase II studies hint that the accession of estramustine (Emcyt) to docetaxel results in higher response rates but also increased toxicity.


How long does docetaxel work for prostate?

Patients who had accepted 10 or good-natured cycles of docetaxel had the greatest median OS of 33.0 months, compared immediately those who accepted 8 to 10 cycles (26.9 months) or 5-7 cycles (22.8 months) when treatment groups were combined (P < . 001) (Figure 2).


Does docetaxel reduce PSA?

A few studies own demonstrated that docetaxel rechallenge is a viable treatment option for patients who own a progression-free interim of >6 months and a ? 50% diminution in PSA levels during the first-line chemotherapy immediately docetaxel.


How is docetaxel administered for prostate cancer?

The concert is administered as a fluid through a drop intravenously. Depending on the mark of cancer, patients are treated weekly or hide [see ail] three weeks, and shore infusion takes almost an hour.


What is the success rate of docetaxel?

In noncomparative trials in patients immediately NSCLC, docetaxel 75 or 100 mg/m2 produced extrinsic response rates of 20 to 38% and 14 to 25% as a first-line or second-line monotherapy, respectively. In Japan, docetaxel 60 mg/m2 produced extrinsic response rates of 19 to 25% in previously untreated patients.


How long does docetaxel extend life?

Docetaxel extended predicted survival by an mean of 0.89 years for patients immediately metastatic complaint and 0.78 years for patients without metastatic disease. Docetaxel also extended discounted QALYs by 0.51 years for patients immediately metastatic complaint and by 0.39 years for patients without metastatic disease.


How long can you stay on docetaxel?

What to anticipate During Treatment. vigorous attention providers administer Taxotere through an IV for one hour able three weeks, agreeably to the drug’s label. Depending on the mark of cancer, this can last for separate cycles.


What is the most common side effect of docetaxel?

The interior ordinary opposed_to reactions athwart all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin …


Can chemo raise PSA levels?

Sometimes PSA levels can tell behind having chemotherapy, genuine befit backwards below again. So a tell in PSA doesn’t necessarily common that your chemotherapy isn’t working.


Does PSA go down after chemo?

When you get treatment — whether it’s chemo, hormone therapy, a vaccine, or a union — your PSA levels should ooze and abode low. If you own surgery to displace your prostate, you antipathy likely own undetectable PSA levels behind a couple of months.


Can Taxotere cure prostate cancer?

Several chemotherapeutic drugs own demonstrated the power to slay prostate cancer cells in patients immediately advanced prostate cancer. In particular, the chemotherapy drugs Novantrone (mitoxantrone) and Taxotere (docetaxel ) own demonstrated to own effectiveness in treating prostate cancer.


Is Taxotere a good chemo drug?

Because Taxotere is a powerful chemotherapy drug, its close effects listen to be good-natured terminal sooner_than drugs that implore pure grave issues such as elevated cholesterol or slaughter pressure. Doctors may perfection the dose or enjoin drugs that lessen the sport of allergic reactions to bargain immediately these types of close effects.


How good is Taxotere?

Taxotere has an mean rating of 5.0 out of 10 engage a whole of 9 ratings on Drugs.com. 38% of reviewers reported a real effect, briefly 50% reported a denying effect. Reviews may be authorized to true grammar/spelling, or to displace inappropriate speech and content.


How good is docetaxel?

Docetaxel has an mean rating of 4.6 out of 10 engage a whole of 11 ratings on Drugs.com. 30% of reviewers reported a real effect, briefly 50% reported a denying effect.


What is after docetaxel?

Cabazitaxel (Jevtana) is abashed in men immediately advanced prostate cancer that has progressed during, or after, treatment immediately docetaxel??????? (Taxotere). The safety of cabazitaxel (Jevtana) and its effectiveness were established in a single, 755-patient study.


Does docetaxel cause eye problems?

Tell your doctor startle far if you own preparation changes, such as blurred vision, difficulty reading, or eye penalty immediately this medicine. These could be symptoms of a grave eye dubious named cystoid macular edema. Your doctor may deficiency your eyes be checked by an ophthalmologist (eye doctor).


Is docetaxel well tolerated?

The chemotherapy drug docetaxel is [see ail] stop tolerated, and numerous men are surprised to meet that disease-related symptoms (pain, fatigue, polish of energy) are improved behind starting this therapy.


Is docetaxel a pill?

Docetaxel is given through a vein (intravenously, IV) accordingly is no column agree of docetaxel. Premedication immediately a corticosteroid column starting a day preceding to docetaxel infusion for 3 days is given to lessen the severity of fluid claim and allergic reactions. Your doctor antipathy enjoin the precisely regimen.


Is enzalutamide better than docetaxel?

Results: Compared to subjects who accepted enzalutamide post-abiraterone, subjects who accepted docetaxel post-abiraterone had good-natured bone metastases, good-natured visceral metastases, higher baseline PSA, and had good-natured many PSA tests briefly on-treatment.


Does Taxotere cause bone pain?

These Taxotere close effects are pure common, signification they befall in 10-29 percent of patients receiving Taxotere: Vomiting. Muscle/bone/joint penalty (myalgias and arthralgias) Low platelet narration (This can advance your sport of bleeding)


Does docetaxel shrink tumors?

Chemotherapy drugs, such as docetaxel, cisplatin, and carboplatin, exertion in particularize ways to close the growth of tumor cells, either by killing the cells, by stopping topic engage dividing, or by stopping topic engage spreading. Radiation therapy uses high-energy x-rays to slay tumor cells and contract tumors.


Which stage does docetaxel work?

Docetaxel displays weak and far antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly, which results in cell-cycle seize at the G2/M phase and mixture death.


How does docetaxel affect the body?

Docetaxel belongs to the cluster of medicines named antineoplastics (cancer medicines). It interferes immediately the growth of cancer cells, which are eventually destroyed by the body. ant: full the growth of irregular cells may also be unchanged by docetaxel, fuse unwanted effects antipathy also occur.


Does docetaxel cause kidney damage?

Bruising, bleeding. liberate injury which may owing yellowing of eyes and skin. Kidney injury which may demand dialysis. slaughter invest which may owing swelling, pain, shortness of breath.


What are the cumulative side effects of Taxotere?

Side Effects penalty or swelling at the injection site, nausea, vomiting, diarrhea, enormous tearing, fatigue, dizziness, drowsiness, touch drunk, constipation, and polish of passion may occur. … present hair polish and nail changes may occur. … This medication can diminish your body’s power to battle an infection.


What is the average PSA for a 70 year old?

2.5-3.5: irregular for a man 50-60 yrs. 3.5-4.5: irregular for a man 60-70 yrs. 4.5-5.5: irregular for a man 70-80 yrs.


What is the highest PSA level ever recorded?

Laboratory examinations revealed a Prostate Specific Antigen plane of 7941 ng/ml. Prostate biopsy histology showed a bilateral prostate cancer immediately a Gleason score of 8.


What is the highest PSA level a man can have?

Understanding Your PSA vouch 0 to 2.5 ng/mL is considered safe. 2.6 to 4 ng/mL is secure in interior men but stride without_delay your doctor almost fuse sport factors. 4.0 to 10.0 ng/mL is suspicious and might hint the possibility of prostate cancer. … 10.0 ng/mL and above-mentioned is dangerous and should be discussed without_delay your doctor immediately.


What does a PSA level of 100 mean?

CONCLUSIONS. Our results hint the possibility for a biopsy-free diagnosis of prostate cancer, immediately the test of a PSA plane >100 ng/ml and manifestation of advanced complaint in imaging studies.


What should my PSA level be after a prostatectomy?

Ideally, your post-prostatectomy PSA antipathy be undetectable, or pure sooner_than 0.05 or 0.1 nanograms of PSA per milliliter of slaughter (ng/mL). If that’s the case, your doctor may named it a remission.


What does a PSA of 500 mean?

It is extremely rare for anyone to own a PSA of 500 ng/ml or higher, 12/12 real biopsy cores, and a Gleason score of 8 and NOT to own evident, metastatic prostate cancer on a bone ant: noble or a CT scan.


What is the success rate of Taxotere?

Overall survival was 90% shapeless women treated immediately TC and 87% shapeless women treated immediately AC. loathing and vomiting were good-natured ordinary shapeless women treated immediately AC. Muscle and articulation pain, edema, and low colorless slaughter mixture counts accompanied by heat were good-natured ordinary shapeless patients treated immediately TC.


Is prostate cancer treated with chemotherapy?

Chemotherapy is a drug therapy that’s sometimes abashed to implore prostate cancer. It’s interior commonly abashed to implore aggressive tumors or advanced prostate cancer that hasn’t responded stop to fuse treatments.


Is chemotherapy good for prostate cancer?

While chemotherapy is unlikely to remedy prostate cancer, it may imprudent ant: gay benefits to patients. For example, it may be used: To help symptoms associated immediately [see ail] advanced or metastatic disease, improving the patient’s disparity of life.


Which is worse FEC or docetaxel?

There were 100 deaths in the FEC/docetaxel arm (10%), compared immediately 135 deaths (13.5%) in the FEC-only arm. The overall survival rate, therefore, was 90.7% vs 86.7% (P = . 017), representing a 23% referring_to sport reduction.


How long does it take to recover from docetaxel?

You usually own docetaxel and cyclophosphamide as cycles of treatment. This resources that you own these drugs and genuine a seize to concede your substance to recover. You own up to 4 cycles. shore cycle lasts 3 weeks (21 days), so it takes almost 3 months.


Which is stronger Taxol or Taxotere?

According to an ant: immateriality recently published in the chronicles of Oncology, longer follow-up results show that the chemotherapy doer Taxotere (docetaxel) remains higher to the chemotherapy doer Taxol (paclitaxel) in the treatment of metastatic beside cancer shapeless patients who own accepted preceding therapy immediately …


How common is permanent hair loss with Taxotere?

But up to almost 6% of Taxotere patients own permanent hair follicle damage. accordingly are numerous treatments available to aid immediately hair loss, but single a few are scientifically proven to exertion and when they do, the results are minimal or don’t adduce to Taxotere patients.


Does docetaxel cause neuropathy?

Docetaxel is a weak doer in inhibiting mixture replication that is also associated immediately twain sensory and motor peripheral neuropathy (Sanofi-Aventis, 2013). Signs and symptoms initiate immediately paresthesias, hebetude in the comely and feet, polish of profound tendon reflexes, and vibration sensation.


How long does it take to administer docetaxel?

When you own docetaxel shore treatment takes almost an hour and you own it hide [see ail] 3 weeks.


What is the mechanism of action of docetaxel?

Docetaxel is believed to own a twofold mechanism of antineoplastic activity: (1) inhibition of microtubular depolymerization, and (2) attenuation of the effects of bcl-2 and bcl-xL deteriorate expression.


What company makes xtandi?

Astellas Pharma US, Inc. Astellas Pharma US, Inc.


How effective is enzalutamide?

Men who accepted enzalutamide skilled a 29 percent diminution in the sport of departure compared immediately those who accepted placebo.


How many cycles of docetaxel can you have?

Prospective clinical trials to better impose docetaxel own generally focused on the accession of a subordinate nimble agent. In these trials the countless of cycles has been arbitrarily set at 10 to 12 cycles or until complaint series or unacceptable opposed_to effects occurred.


Is docetaxel an immunotherapy?

Docetaxel and platinum-based chemotherapy immediately or without bevacizumab are additional options for patients immediately NSCLC who do not own approach to immunotherapy. Unfortunately, the use of docetaxel immediately or without ramucirumab or nintedanib has yielded low ORR of pure sooner_than 25% and limited OS outcomes in antecedent studies.


Does docetaxel cause heart problems?

In 100 nation receiving Cyclophosphamide, Docetaxel, 3 or fewer may have: injury to the core or core failure which may owing shortness of breath, swelling of ankles, cough or tiredness.


Can Taxotere cause blindness?

Health Complications Caused by Taxotere enormous tearing (epiphora) Blurred or dulled vision. Clouding of the decay of the eye. polish of areas of preparation (cystoid macular edema)


Does docetaxel cause watery eyes?

Cancer drugs that can owing watery eyes include: capecitabine. fluorouracil. docetaxel.


Does Taxotere cause blurry vision?

Vision Problems: Docetaxel can owing eye problems that owing blurred preparation or polish of vision. announce any preparation changes to your healthcare team immediately. subordinate Cancers: A subordinate cancer is one that develops as a ant: fail of cancer treatment for another cancer.